A Novel Topology of Proline-rich Transmembrane Protein 2 (PRRT2)
نویسندگان
چکیده
منابع مشابه
A novel topology of proline-rich transmembrane protein 2 (PRRT2): Hints for an intracellular function at the synapse.
Proline-rich transmembrane protein 2 (PRRT2) has been identified as the single causative gene for a group of paroxysmal syndromes of infancy, including epilepsy, paroxysmal movement disorders, and migraine. On the basis of topology predictions, PRRT2 has been assigned to the recently characterized family of Dispanins, whose members share the two-transmembrane domain topology with a large N term...
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s | 269 the number, mean duration and total duration of spike wave discharges (SWD) were evaluated using EEG recordings. Each group was then divided into two subgroups. In the first group mean arterial blood pressure (MAP) and heart rate (HR) measurements were performed. In the second group, in vitro isolated organ studies were conducted on the thoracic aortas of animals. Results: ETX treatment...
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BACKGROUND AND PURPOSE Given the diverse phenotypes including combined non-dyskinetic symptoms in patients harboring mutations of the gene encoding proline-rich transmembrane protein 2 (PRRT2), the clinical significance of these mutations in paroxysmal kinesigenic dyskinesia (PKD) is questionable. In this study, we investigated the clinical characteristics of PKD patients with PRRT2 mutations. ...
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Transmembrane (TM) proteins (TMPs) have important roles in the biological organisms [1, 2]. With the rapid increasing of the number of TMPs, a lot of efforts are made in attempt to classify TMP functions by sequence analysis, and in fact, some databases aimed for it have been constructed (e.g., Pfam [3]). Which characteristics of TMP could provide us important clues to its function? We suppose ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2016
ISSN: 0021-9258
DOI: 10.1074/jbc.m115.683888